ABSTRACT
Effects of methylflavonolamine (MFA) on arachidonic acid(AA) metabolism pathway were studied. MFA (iv 40 mg ? kg-1) lightened the acute pulmonary thromboenblism signs in mice and reduced the mortality induced by AA. MFA(12. 5~200?mol ? L-1) in vitro dose-dependently inhibited rabbit platelet aggregation induced by AA. MFA(0.1~0. 4mmol ? L-1) in vitro dose - dependently inhibited rabbit platelet malondiadehyde(MDA) formation in-duced by AA. MFA(0. 4mmol?L-1) inhibited platelet MDA formation in rabbits induced by thrombin and AA. While propranolol inhibited MDA formation induced by thrombin but not by AA. MFA (0.4 mmol ? L-1) did not affect cAMP content in rabbit platelet. These results suggest that inhibitory effect of MFA on platelet AA metabolism may be one of the mechanism by which MFA inhibited platelet aggregation.
ABSTRACT
Effects of thioproline on thrombus formation and platelet function were studied. Thioprolline given in vitro ( 1 g/L ) or ex vivo ( iv 25mg /kg ) shortened length of thrombi and decresed the wet and dry weight of thrombi in rabbits or rats. Thioproline given iv vitro ( 1 g/L ) or ex vivo ( iv 50mg/kg ) inhibited platelet adhesion and aggregation induced by ADP in rabbits.